About Apogee Therapeutics

Founded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. At Apogee, you can actively contribute to shaping the company culture, take on various roles and responsibilities, and grow professionally.

Apogee Therapeutics is a clinical-stage biotechnology company advancing novel biologics with potential for differentiated efficacy and dosing in the largest I&I markets, Apogee’s antibody programs are designed to overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. Zumilokibart (APG777), the company’s most advanced program, is being initially developed for the treatment of atopic dermatitis (AD), which is the largest and one of the least penetrated I&I markets, as well as asthma. With four validated targets in its portfolio, Apogee is seeking to achieve best-in-class efficacy and dosing through monotherapies and combinations of its novel antibodies. Based on a broad pipeline and depth of leadership and expertise, the company believes it can deliver value and meaningful benefit to patients underserved by today’s standard of care.

We are a fast-paced company committed to building an exceptional culture, founded on our C.O.R.E. values: Caring, Original, Resilient and Egoless and a commitment to refusing to stop at “good enough”.

If this sounds like you, keep reading!

Role Summary

We are seeking a highly experienced and motivated individual to lead our biomarker efforts in the field of inflammatory and immune diseases, with a focus on atopic dermatitis, asthma, COPD and EOE. Reporting to the Senior Vice President – Research and Translational Medicine, the successful candidate will be responsible for overseeing the strategy and implementation of all our translational clinical and preclinical biomarker programs from early but particularly late-stage development including Phase 3 trials and BLA-readiness for all our assets. As Vice President – Inflammatory and Immune Disease Biomarker Development you will be leading and growing our internal team as well as our network of external vendors and collaborators.

If you are a driven and innovative senior leader with a passion for biomarker development in I&I diseases as well as a deep late-stage clinical development understanding, we encourage you to apply for this exciting opportunity to make a meaningful impact on the lives of patients.

Key Responsibilities

Lead the strategic planning and execution of biomarker discovery and development programs for inflammatory and immunology diseases, focusing on atopic dermatitis, asthma, COPD and EOE and particularly late-stage clinical development
Develop and articulate the late-stage clinical and post-launch strategic vision for the biomarker programs to internal and external stakeholders
Collaborate with internal and external stakeholders to integrate our biomarker discovery and development efforts into our development programs, including clinical trials and BLAs
Oversee the Biomarker Discovery and Development team to drive efforts through a combination of in vitro/in vivo and in silico data analyses, in house and in collaboration with external partners
Together with the Senior Director-Biomarker Discovery and Development develop and implement biomarker strategies to demonstrate the clinical utility of novel biomarkers and the distinction of patient populations and responders as well as additional indications
Stay current on emerging trends and technologies in biomarker discovery and development, and implement best practices to ensure the success of our programs
Provide strategic input and leadership to cross-functional program and functional teams to drive the development of novel, innovative therapies for inflammatory and immunology diseases

Ideal Candidate

PhD or MD in a relevant scientific discipline with at least 15 years of track-record in senior leadership roles in biomarker discovery and development, preferably in the field of inflammatory and immunology diseases
Proven success in leading biomarker discovery programs from ideation to clinical validation and a focused understanding on late-stage clinical development including Phase 3 trials with biologics and BLAs is required. Experience in I&I, atopic dermatitis, asthma, COPD and/or EOE a plus
Excellent communication skills and ability to articulate and communicate complex strategic vision with a variety of internal and external stakeholders
Deep hands-on knowledge of the antibody development process and regulatory requirements for biomarkers in clinical trials and for BLA-submissions. Strong preference for candidates with late stage clinical and post launch experience
Expertise in collaborating with external partners and key opinion leaders in the field of inflammatory and immunology diseases
Strong leadership and communication skills fully aligned with our C.O.R.E. values, with the ability to effectively lead your internal team and fully integrate this team from early- to late-stage clinical development efforts
Position requires up to 30% travel including mandatory in-person attendance at All Hands meetings typically held twice per year as well as travel to Apogee offices in Boston and San Francisco.

The anticipated salary range for candidates for this role will be $320,000-$355,000 per year. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.

What We Offer

A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless
Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly
Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
We provide competitive time off, including three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave
Commitment to growing you professionally and providing access to resources to further your development
Apogee offers regular all team, in-person meetings to build relationships and problem solve

E-Verify Participation: As part of the I9 verification of authorization to work in the US, Apogee participates in E-Verify. To learn more about E-Verify please review this poster.

Apogee Therapeutics is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

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It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Vice President, Inflammatory and Immune Disease Biomarker Development

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