Senior Research Associate, in vivo Biology

Job Title:

Senior Research Associate, in vivo Biology

Location:

San Diego, CA

Position type:

FLSA:

Full time

Non-Exempt

Department:

Finance ID:

Biology

1201-R55492-BF

Profoundly Improve People’s Lives by Revolutionizing the Delivery of RNA Therapeutics

At Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people’s lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients. 

Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs™). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit www.aviditybiosciences.com and engage with us on LinkedIn and X.

The Opportunity

We are seeking an experienced in vivo Biology Research Associate to characterize in vivo properties of novel therapeutic Antibody Oligonucleotide Conjugates that deliver nucleic acids. The candidate will be part of a small team responsible for executing in vivo animal studies across multiple projects, including PK, PD, and biomarker analyses. Prior experience with rodent handling, multiple dosing routes, blood collection, and tissue sample collection is required. The associate will closely collaborate with colleagues in pre-clinical discovery and present scientific results to multidisciplinary teams and senior management.

What You Will Contribute

• Drive forward preclinical research projects to expand Avidity’s AOC platform through in vivo data.
• Research and incorporate new techniques, when applicable, to expand in vivo team capabilities
• Provide input on in vivo experimental design across platform projects.
• Collaborate with team members across multiple departments throughout Avidity to deliver on corporate goals

What We Seek

• B.S./B.A. degree in the biological sciences with at least 2+ years of relevant in vivo animal study experience, preferably in an industry setting
• Proficient in various mouse and rat dosing techniques – IV, SC, IP, RO, ICV, ITH. Must have high proficiency in IV dose administration in C57BlL/6 background mice.
• Proficient in survival and terminal bleeding techniques – RO, Tail, Submental, Cardiac.
• Demonstrate proper handling of biological samples and protein biologics
• Knowledge of laboratory rodent behavior, anatomy, and guiding principles for animal welfare
• Surgical and/or micro-dissection experience preferred
• Strong organizational skills and attention to detail, including the ability to manage several projects simultaneously.
• Proficient computer and data collection/analysis skills - Microsoft Office Suite, Prism, Benchling preferred
• Ability to work and troubleshoot independently and in a team setting.

Physical Requirements/Demands

• Repetitive motions that may include the fingers, wrists, hands, and/or legs
• Remaining in a stationary position, often standing or sitting for prolonged periods
• Adjusting or moving objects up to 50 pounds.
• Operating machinery and laboratory equipment
• Exposure to animal allergens

Environmental Conditions

• Low and Vivarium temperatures
• Noisy environments
• Exposure to general laboratory and vivarium environment conditions.
• Exposure to general office environment conditions.

What We Will Provide To You

• The base salary range for this role is $40/hr. - $45/hr. The final compensation will be commensurate with relevant experience, skillset, internal equity, and market factors.
• Avidity offers competitive compensation and benefits, including the opportunity for annual and spot bonuses, stock options, and RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD and four weeks of time off.
• A commitment to learning and development, including a variety of internal programming developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.