Senior Manager, Clinical Trial Liaison

The Role: 

We are seeking an experienced Senior Manager, U.S. Clinical Trial Liaison (CTL) to serve as a key bridge between Generate:Biomedicines and U.S. clinical research sites. This is an individual contributor role that partners closely with investigators, site staff, Clinical Operations, and CRO partners to support the compliant, high-quality execution of our clinical trials.

The Senior Manager, CTL will drive site engagement, training, and enrollment support across assigned U.S. sites while identifying operational risks and opportunities to improve study execution from start up to close out. This role also contributes to consistent site-facing practices.

Work Type: U.S.-based, field-based role with up to 60% travel

Here's how you will contribute:

• Serve as the primary sponsor contact for assigned U.S. clinical trial sites, ensuring consistent, responsive communication throughout study execution.
• Build strong relationships with investigators and site staff to support site engagement, trial readiness from start up to close out, and sustained study performance.
• Deliver training to site personnel on study protocols, operational requirements, study objectives, and the scientific rationale for investigational products.
• Partner with sites to support patient recruitment and retention strategies, helping to identify barriers and opportunities to improve enrollment.
• Collaborate closely with Clinical Operations and CRO partners to identify, address, and escalate operational or compliance issues in a timely manner.
• Conduct remote and in-person site visits to strengthen site relationships, gather feedback, provide sponsor oversight and support effective trial execution.
• Capture and communicate actionable insights from sites to inform study operations, enrollment planning, and protocol execution.
• Contribute to feasibility assessments and site selection activities by sharing knowledge of local treatment practices, site capabilities, and patient access considerations.
• Support consistent execution across assigned sites by reinforcing study expectations, compliance standards, and best practices.

The Ideal Candidate will have:

• Bachelor’s degree in a scientific, healthcare, or related field required. Advanced degree preferred but not required.
• 6+ years of clinical trial experience in the pharmaceutical, biotech, or CRO industry, including strong knowledge of clinical operations and study conduct.
• Previous experience working in a clinical trial liaison role or role with similar scope.
• Demonstrated experience working directly with investigators, site staff, and cross-functional clinical teams to support study delivery and enrollment goals.
• Working knowledge of GCP, ICH guidelines, and U.S. regulatory requirements.
• Ability to independently manage multiple sites and priorities while exercising sound judgment in a dynamic environment.
• Strong communication, collaboration, problem-solving, and relationship-building skills.
• Experience using clinical trial systems such as IRT, EDC, and eTMF.
• Willingness and ability to travel up to 60% for site engagement, meetings, and study-related activities.

Nice to Have:

• Experience in respiratory, immunology, or oncology clinical trials.
• Prior CRA experience.
• Experience supporting site activation, enrollment acceleration, or patient retention initiatives.
• Familiarity with AI-enabled tools or digital platforms used in clinical development.

Who Will Love This Job:

At Generate, you will be part of a team reshaping the future of drug development through Generative Biology™. You will work alongside driven colleagues, help bring novel therapeutics to patients faster, and grow in an environment that values curiosity, collaboration, scientific rigor, and bold thinking. This is an opportunity to make a meaningful impact on clinical trial execution while contributing to a company built to change what is possible for patients.

About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.

Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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