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Ginkgo Bioworks Inc.

Senior Engineer I, Science

Boston , United States
Hybrid

AI overview

Contribute to the modernization of ADME through high-throughput screening for drug discovery, utilizing state-of-the-art automation and analytical techniques.

Our mission is to make biology easier to engineer. Ginkgo is constructing, editing, and redesigning the living world in order to answer the globe’s growing challenges in health, energy, food, materials, and more. Our bioengineers make use of an in-house automated foundry for designing and building new organisms. 

 

Here at Ginkgo, we are aiming to modernize ADME by bringing our experience in high-throughput screening to the in vitro small molecule drug pipeline. We are re-imagining ADME at scale, and we are seeking a visionary and technically adept High-Throughput ADME Scientist to help us build and execute this next-generation platform. This role is critical in accelerating our drug discovery pipeline by providing timely and high-quality in vitro ADME (Absorption, Distribution, Metabolism, and Excretion) data to guide lead optimization.

The ideal candidate will possess deep technical expertise in developing, validating, and implementing a variety of high-throughput ADME assays.

Key Responsibilities

Assay Development & Implementation

  • Design, develop, optimize, and validate a wide array of high-throughput in vitro ADME assays (e.g., solubility, MDCK permeability, plasma protein binding, microsomal stability, hepatocyte stability, and CYP inhibition/induction).
  • Automation and Screening: Experience working with automated liquid handlers such as Hamilton, Lynx, Bravo, and Formulatrix.

Data Analysis & Reporting

  • Develop and perform mass spectrometry (LC-MS/MS, acoustic ejection mass spectrometry, or similar) analysis of samples from ADME assays. Responsibilities will include method development and troubleshooting.
  • Ensure proper sample preparation and management for high-throughput analysis.
  • Analyze, interpret, and report complex ADME data, including calculating key pharmacokinetic parameters.
  • Present results and provide expert recommendations to medicinal chemists and project teams to inform go/no-go decisions.

Quality & Compliance

  • Maintain detailed and accurate laboratory records, SOPs, and electronic notebooks.
  • Ensure all laboratory activities comply with internal quality standards and safety regulations.

Minimum Qualifications

  • Education: Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or a related field with 2+ years of relevant industry experience, or a Master's degree with 5+ years of industry experience.
  • Technical Expertise:
    • Extensive, hands-on experience with LC-MS or acoustic MS particularly in a high-throughput setting.
    • Proven track record in developing and running automated in vitro ADME assays using state-of-the-art laboratory automation.
    • Strong theoretical and practical knowledge of drug metabolism pathways and DMPK.
    • Familiarity with common ADME prediction software and data visualization tools.

 Preferred Skills

  • Experience using lab automation.
  • Programmatic coding experience (e.g., Python, R, or similar).
  • Data visualization (Spotfire, Python, R, or similar).
  • Experience handling clinical samples.
  • Familiarity with working in a CRO (Contract Research Organization) environment or managing CRO relationships.
  • Proficiency with electronic laboratory data capture systems (e.g., LIMS, ELN).

The base salary range for this role is $115,000.00 - $165,000.00. Actual pay within this range will depend on a candidate's skills, expertise, and experience. We also offer company stock awards, a comprehensive benefits package including medical, dental & vision coverage, health spending accounts, voluntary benefits, leave of absence policies, 401(k) program with employer contribution, 8 paid holidays in addition to a full-week winter shutdown and unlimited Paid Time Off policy.

Ginkgo has implemented a return to office policy effective October 1, 2025 with required in-office days: Tuesday, Wednesday, Thursday.  This policy applies to all employees who live within 50 miles of Ginkgo’s offices in Boston, MA, Emeryville, CA and West Sacramento, CA. **Biosecurity positions are excluded from this policy. 

 
It is the policy of Ginkgo Bioworks to provide equal employment opportunities to all employees, employment applicants, and EOE disability/vet. 
 
 
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 Ginkgo Bioworks Inc.

Important Notices: If you have a disability and you wish to discuss potential accommodations related to applying for employment, please contact [email protected].   Recruitment & Staffing AgenciesGinkgo Bioworks does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Ginkgo or its employees is strictly prohibited unless contacted directly by Ginkgo’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Ginkgo Bioworks, and will not owe any referral or other fees with respect thereto.   Scam AlertPlease be aware of the potential for scams from individuals, organizations and internet sites that claim to represent Ginkgo Bioworks, Inc. in recruitment activities. Ginkgo conducts a formal recruitment process for all authorized positions posted and does not conduct interviews via social media or other third-party sites. This site is secure and any applications made here will feed to our legitimate Applicant Tracking System. If you’re contacted by a Ginkgo Recruiter, please ensure whomever is contacting you truly represents Ginkgo. We will never ask for the exchange of any money or credit card details during the recruitment process. Please be aware of any suspicious email activity from people who could be pretending to be recruiters or senior professionals at Ginkgo and please report any suspicious recruiting activity to: Your state’s Attorney General’s OfficeInternet Crime Complaint CenterUSA.govBetter Business Bureau     

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Salary
$115,000 – $165,000 per year
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