This is an exciting opportunity for a scientist to join a fast-paced, fast-growing research organization based in SoHo. We are seeking a scientist to develop and run novel workflows for adaptive immune cells. The successful candidate will have experience in B and T cell isolation, flow cytometry, tissue culture, and sequencing – and can perform hands-on wet lab experimentation with a variety of immunological assays. The successful candidate will develop novel immune repertoire assays and datasets, working closely with our multidisciplinary team of senior scientists and computational immunologists.
IMPRINT is a biomedical Focused Research Organization(FRO) building and applying experimental and machine learning tools to identify the hidden causes of chronic disease, especially autoimmune and psychiatric disorders. FROs are moonshot nonprofit startups. Combining the excitement and efficiency of startups with the scientific impact of academia, this role offers hybrid experience in both industry and academia. Our work involves cutting-edge research at the intersection of immunology, machine learning, neuroscience, and disease.
Primary Responsibilities
Immune cell isolation, tissue culture, and sterile technique
Design, plan, and execute NGS-based assays in coordination with interdisciplinary science teams
Prepare DNA and RNA library preparation from immune cells
Help develop novel sorting methods for B and T cells
Help develop multi-omics sequencing workflows (e.g., 10x Genomics, LIBRA-seq)
Analyze and present data
Creatively solve challenging experimental problems
Setup, operate, and maintain instrumentation (incubators, shakers, flow cytometer, sequencers)
Assist in procurement and maintenance of supplies, chemicals, and biological inventories
Perform other duties as requested
Qualifications
PhD in Molecular Biology, Immunology, Biochemistry, Bioengineering or related fields is required OR a BA/MS with >5 years industrial experience
At least 5 years of hands-on research experience with immunology techniques is required
At least 1 year of experience conducting milestone-driven R&D is required (industry, startup, ARPA experience, or equivalent)
Demonstrated proficiency in molecular biology and sterile techniques
Creative thinking and problem-solving skills
Strong quantitative and analytical skills
Strong communication and teamwork skills
Ability to set priorities and meet deadlines
Ability to adapt to changing projects and goals
Passion for breaking barriers in immunology
Preferred Qualifications
Experience with antigen labeling
Experience with antigen generation
Experience with adoptive transfer
Experience with bulk or single-cell sequencing (wetlab) and analysis (bioinformatics)
Experience with AIRR-seq / BCR-seq or LIBRA-seq
Experience with any of following: antibody isolation from plasma, directed evolution
Proficiency coding in Python/R/Matlab, esp. for data analysis
Familiarity with project management methodology
Experience with primary human sample processing (i.e., PBMC, plasma, tissue)
High proficiency with nucleic acid preparation from adaptive immune cells
Proven track record of custom library-preparation development for next-generation sequencing
Benefits
Competitive salary: $100,000 - $120,000 a year (salary commensurate with relevant experience and adjusted for location)
Health, vision, and dental insurance
Generous time off and paid holidays
Company 401(k) match up to 6%
Wellness allowance
