Lead Product Manager, Clinical Genomics Engineering

Natera offers genetic risk assessment and diagnostic tests to patients through medical providers. The Clinical Genomics Engineering organization builds software that supports complex, regulated workflows spanning tertiary analysis workflows including variant  interpretation, clinical review, and reporting. As Natera scales across Women’s Health, Oncology, and Organ Health, delivering  cohesive, reliable, and compliant software experiences is foundational to clinical quality and commercial success.

Natera is seeking a Lead Product Manager to define and drive strategy for core components of the Results, Interpretation, and Reporting (RIR) platform. This role is responsible for shaping scalable, compliant, and cohesive clinical software systems that support complex genomics workflows across multiple business units. The Lead PM will operate as a platform-level owner, ensuring long-term architectural soundness, regulatory robustness, and measurable clinical and operational outcomes.

Initial Focus and Scope Evolution

The Lead Product Manager will lead cross-functional alignment across engineering, clinical, quality, and downstream systems to ensure RIR components operate as a cohesive, scalable platform. This role will identify systemic gaps, resolve cross-team tradeoffs, and drive architectural and workflow decisions that support long-term growth and regulatory compliance.

This role will initially own one or more RIR software components or initiatives, with responsibility for defining long-term strategy, aligning cross-component workflows, and ensuring scalable architecture across user-facing applications, data contracts, and backend services. The Lead PM will drive strategic investment decisions, establish standards for usability and reliability, and ensure systems meet evolving clinical, operational, and regulatory requirements.

As business needs evolve, this role will expand to influence and coordinate across multiple RIR components, driving cohesive workflow design, shared data standards, and platform-level scalability across Women’s Health, Oncology, and Organ Health.

Primary Responsibilities

• Define and drive multi-year product strategy and roadmap across one or more RIR components, ensuring alignment to clinical quality, regulatory requirements, and commercial scale objectives

• Influence platform-level technical direction in partnership with engineering leadership 

• Partner closely with software engineering, bioinformatics, clinical domain experts, quality, regulatory, and other product teams

• Translate business, clinical, and operational needs into clear, actionable product requirements

• Define and evolve end-to-end user workflows, including UI/UX requirements and supporting backend functionality

• Drive cross-team alignment on shared data contracts and workflow standards

• Mentor and raise the bar for product management within the RIR organization

• Own measurable improvements in clinical workflow efficiency, reliability, and operational scalability

• Establish prioritization frameworks that balance regulatory risk, clinical impact, technical scalability, and business outcomes across RIR investments.

• Develop and track quantitative metrics related to usability, performance, reliability, and adoption

• Lead delivery teams with clear strategic direction, ensuring requirements reflect long-term platform goals, validation readiness, and system interoperability.

• Proactively identify systemic risks, architectural constraints, and workflow inefficiencies that may limit scale or regulatory robustness, and lead cross-functional initiatives to resolve them

• Partner with Quality and Regulatory leadership to shape validation strategy, risk classification, traceability, and audit readiness for RIR software systems.

• Create clear, data-driven written proposals and presentations to support stakeholder alignment and decision-making

• Act as a subject matter expert for owned components, supporting design, testing, validation, rollout, and ongoing use

Qualifications

Required

• Bachelor’s degree in life sciences, engineering, computer science, statistics, or equivalent experience

• 7+ years of experience in software product management, including ownership of complex, multi-team or platform-level initiatives

• 5+ years experience working on production software in healthcare, clinical genomics, or other regulated lifesciences domains, with demonstrated impact on validation, compliance, and system scalability

• Demonstrated experience influencing engineering architecture and long-term technical investment decisions

• Proven ability to drive alignment across highly matrixed organizations without direct authority
  Track record of independently operating in ambiguous environments and establishing product direction
  

Preferred

• Experience with clinical genomics and variant processing and interpretation workflows

• Experience owning user-facing applications, tools, or operational software

• Familiarity working with backend services, APIs, or data-driven systems

Knowledge, Skills, and Abilities

• Ability to operate effectively at both tactical and strategic levels, connecting detailed execution to broader platform vision.

• Strong analytical skills with attention to quality, reliability, and user outcomes

• Leads technical design discussions and critically evaluates architectural tradeoffs to ensure scalability, reliability, and regulatory integrity

• Proven ability to influence without authority and drive alignment across teams

• Clear, concise written and verbal communication skills across technical and non-technical audiences

• Ability to manage multiple initiatives in a fast-paced, regulated environment

• Familiarity with Next Generation Sequencing concepts is beneficial