Zenas is a clinical-stage global biopharmaceutical company committed to becoming a leader in the development and commercialization of transformative therapies for patients with autoimmune diseases. Our core business strategy combines our experienced leadership team with a disciplined product candidate acquisition approach to identify, acquire and develop product candidates globally that we believe can provide superior clinical benefits to patients living with autoimmune diseases. Zenas is advancing two late-stage, potential franchise molecules, obexelimab and orelabrutinib. Obexelimab, Zenas’ lead product candidate, is a bifunctional monoclonal antibody designed to bind both CD19 and FcγRIIb, which are broadly present across B cell lineage, to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. We believe that obexelimab’s unique mechanism of action and self-administered, subcutaneous injection regimen may broadly and effectively address the pathogenic role of B cell lineage in chronic autoimmune disease. Orelabrutinib is a potentially best-in-class, highly selective CNS-penetrant, oral, small molecule Bruton’s Tyrosine Kinase (BTK) inhibitor with the potential to address compartmentalized inflammation and disease progression in Multiple Sclerosis (MS). Zenas’ earlier stage programs include a preclinical, potentially best-in-class, oral, IL-17AA/AF inhibitor, and a preclinical, potentially best-in-class, oral, brain-penetrant, TYK2 inhibitor.

We are seeking top talent who share our commitment to patients and have a track record of success in acquiring, developing and commercializing products across the globe. Our colleagues have an opportunity to engage in a fast-paced learning environment and experience individual and organizational success as we work towards becoming a global immunology and autoimmune disease leader, while living our values of Transparency, Relationships, Urgency, Excellence and Innovation – TRUE Innovation!

Position Summary:

The US East Medical Science Liaison Manager, Rheumatology, at Zenas is a key Medical Affairs leader responsible for hiring, developing, and managing a high-performing team of Medical Science Liaisons. This role ensures scientific excellence, compliant external engagement, strategic alignment with medical plans, and the generation of high-quality insights to advance the company’s therapeutic priorities. The ideal candidate combines strong leadership, deep scientific expertise, and operational discipline to support product launches and lifecycle management. This position reports to the Executive National Director, Medical Science Liaisons.

Key Responsibilities:

Field Team Leadership & Development

Manage (recruit, train, coach, and mentor) a team of MSLs to ensure scientific, operational, and compliance excellence.
Conduct regular field rides/virtual shadowing to observe skills, provide feedback, and support professional development.
Set clear performance expectations and conduct ongoing performance evaluations.
Foster a culture of collaboration, accountability, and continuous improvement.

Scientific Strategy & Execution

Translate the Medical Affairs strategy into actionable field medical plans.
Guide the MSL team on priority scientific topics, key data updates, competitive landscape, and disease state knowledge.
Ensure consistent, high-quality insights-driven scientific exchange in alignment with approved materials and compliance standards.
Support development and delivery of scientific training for field teams and cross-functional stakeholders.

Stakeholder Engagement

Oversee relationship-building with key opinion leaders (KOLs), academic investigators, and professional societies.
Ensure KOL identification, mapping, and engagement plans are aligned to strategic medical objectives.
Partner effectively with Clinical Development, Medical Directors, HEOR, and Commercial (within compliance) to ensure coordinated insights and activities.

Insight Generation & Medical Intelligence

Establish processes for capturing, synthesizing, and communicating field insights to Medical Leadership and cross-functional teams.
Identify emerging trends, data gaps, and unmet needs that inform clinical strategy, medical education, and evidence generation plans.

Cross-Functional Collaboration

Ensure appropriate collaboration with Clinical Operations (site support), Safety/Pharmacovigilance, Regulatory, and Commercial teams in alignment with policies.
Contribute to advisory boards, congress planning, scientific narrative development, and launch readiness.
Partner in the development and execution of scientific resources and medical education initiatives.

Compliance & Operational Excellence

Ensure all field medical activities adhere to regulatory, legal, medical, and company policies.
Oversee activity reporting, CRM documentation, territory planning, and field metrics.
Manage MSL budgets (travel, training, congresses) responsibly and transparently.
Support the Medical-Legal-Regulatory (MLR) process as needed for field materials.

Qualifications:

Advanced clinical/science degree or health care professional credentials required (MD, PhD, PharmD, NP, PA, with significant scientific experience).
5+ years MSL or field medical experience.
Therapeutic area experience preferred.
Strong scientific and clinical acumen with the ability to simplify complex data.
Exceptional leadership, coaching, and talent development capabilities.
Excellent communication, presentation, and interpersonal skills.
Ability to analyze insights, identify trends, and translate them into strategy.
Discipline in planning, organization, compliance adherence, and documentation.
Ability to thrive in a fast-paced, high-growth biotech environment.
Proven track record of building external relationships and driving scientific strategy in the field.
Experience supporting product launch is highly desirable.
Proven track record of success.
Current knowledge & full understanding of all relevant industry, legal, and regulatory compliance guidelines
Commitment to the highest ethical, legal, regulatory, and scientific standards

Travel

Approximately 50–60% travel for KOL engagements, field rides, meetings, and conferences.

#LI-Remote

Zenas is committed to fair and equitable compensation practices. The base salary pay range for this role is $202,400 to $253,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.

Zenas believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Zenas’ competitive total rewards strategy that also includes annual performance bonus, equity, full range of benefits and other incentive compensation plans.

Zenas BioPharma is proud to be an equal opportunity employer. We are committed to fostering an environment where diversity is valued. All qualified applicants will receive consideration for employment based on merit, qualifications and the needs of the business.

Director, US East Medical Science Liaison (MSL) Manager

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