Biostatistics Lead

At PicnicHealth, we're building the future of non-interventional clinical research, powered by AI and centered on patients. Our mission is to make it radically easier, faster, and more affordable to generate high-quality real-world evidence. We're replacing the legacy, services-heavy model with a modern, AI-first approach that unlocks insights from rich, multi-modal data—from clinical notes and imaging to lab results—at scale.  By engaging patients directly through our personal health assistant, PicnicAI, which meets them where they’re at and delights them along the way (with an industry leading NPS of 76), patients participate actively in the research they care about.

PicnicHealth is already a trusted partner to 7 of the top 10 pharmaceutical companies. Our work spans 40+ disease areas and has supported over 60 peer-reviewed publications, including an FDA submission that incorporates PicnicHealth data.

Founded in 2014, we’ve raised $100M+ from top investors like Amplify Partners, Felicis Ventures, B Capital Group, and Y Combinator. Our business running non-interventional studies more than doubled last year, and we’re growing even faster in 2025. We’re a team of doctors, patients, data nerds, engineers, and builders, reimagining how clinical research works — and we’re just getting started!

The Opportunity

We are seeking a Biostatistics Lead to lead and scale the biostatistics function at PicnicHealth. You will be the subject matter expert responsible for establishing best-in-class processes, mentoring a growing team, and directly impacting the scientific rigor and success of our non-interventional research studies. This is a role for a strong people manager who is excited to build a tech-forward team that delivers high impact results for our life sciences partners.

At PicnicHealth, AI is at the core of everything we do. We're looking for individuals who are not just comfortable with, but genuinely excited by and actively experimenting with, the power and potential of AI.

What you’ll do:

• Own the biostatistics function within our delivery team, including managing and scaling a high-performing team of biostatisticians to meet the demands of our growing non-interventional study portfolio that leverages both primary (e.g., PROs, ClinROs, wearables) and secondary data (e.g., medical records, claims).
• Define and implement the operational roadmap for Biostatistics, establishing the standards, processes, and best practices for delivering efficient, high-quality statistical deliverables. 
• Serve as a senior biostatistics partner to internal teams and external clients, providing expert consultation to shape study strategy and build long-term, confident partnerships.
• Provide senior strategic oversight for all client-facing statistical matters, taking ultimate accountability for resolving methodological challenges.
• Champion and integrate AI and other novel technologies to enhance analytical capabilities, drive efficiency, and establish our team as an industry leader in tech-forward research.
• Occasionally roll  up your sleeves to lead and execute complex analyses on key projects while the team scales.

What You’ll Bring:

• An advanced degree (MS or PhD) in Biostatistics, Statistics, or a related quantitative field.
• 10+ years of experience in biostatistics within the life sciences (pharma, biotech, CRO)
• At least 5 years of direct people management experience and comfort managing both junior and senior team members
• Deep, hands-on expertise in statistical methods for observational and real-world evidence (RWE) studies, including external control arms (ECAs), application of causal inference methods (e.g., propensity score matching, marginal structural models), and advanced techniques for imputation and handling of missing data.
• Proven ability to lead consultative interactions with senior client stakeholders, with exceptional communication skills, executive presence, and the ability to instill confidence.
• Expertise with multiple real-world data sources (medical records, claims, wearables, PROs, ClinROs). 
• Expert proficiency in R and the tidyverse; experience with SAS or Python is a plus.
• Experience with regulatory interactions (e.g., FDA, EMA) 
• Familiarity with clinical ontologies (e.g., ICD, RxNorm, SNOMED, LOINC, MedDRA, WHO-DD) and standard data formats (e.g. OMOP, SDTM, ADaM).
• Demonstrated experience building or scaling team processes, including creating SOPs, standard documentation, and QC/review workflows.
• Focus on and successful experimentation with, integrating AI into your standard practices and workflows, and ideas for new applications here at PicnicHealth. 

We expect all team members to be amazing in their roles and, ultimately, to move the PicnicHealth mission forward.

Why will PicnicHealth win in Clinical Research?

Trials are a major bottleneck in drug development, and the promising advancements in biotech cannot achieve their full potential unless clinical research becomes more effective.  The industry runs on outdated technology and manual processes. Research sites (hospitals, academic centers, doctors' offices) are a major bottleneck, and contract research organizations (CROs) spend most of their time wrangling sites and cobbling together vendor software.

PicnicHealth has built technology that uniquely positions us to run faster, cheaper, and more flexible studies without requiring sites:

• PicnicAI (trained on 350M+ clinician annotations over 100k+ patient records) is the only system that can effectively access and structure all participant EMR data trials need
• Our AI health assistant (NPS of 66 in 2024) guides participants through study activities and enables most to be done at home

• We're an integrated solution — virtual site, CRO, and software platform — with AI built in from the ground up, initially focusing on observational research. 

The other perks & benefits you get when you work at PicnicHealth   

We pay competitive salaries. Everyone on the team is an owner: all full time employees get competitive equity.

Target Base Salary Range: $190K - $220K 

The base salary PicnicHealth offers may vary depending upon the scope, complexity, and autonomy of the position and on the candidate’s job-related knowledge, skills, and experience. 

We’re a remote first company, with teammates spread across the US. We support in-person gatherings, including co-working spaces and multi-day onsites, to build connections and move forward strategic initiatives. Expect to travel 2-4 times a year.  For our team members in the Bay Area, who prefer to work in person we can offer a hybrid set up to work from the SF office on a flexible schedule.

You also get:

• Comprehensive benefits including above market Health, Dental, Vision
• Family friendly environment 
• Flexible time off
• 401k plan
• Free PicnicHealth account
• Equipment and internet funds for home office set up 
• Wellness Stipend

PicnicHealth is committed to promoting an inclusive work environment free of discrimination and harassment. We value a diverse and balanced team where everyone can belong.