Associate Director, Portfolio Analytics

THE ROLE

The Associate Director of Portfolio Business Analytics is a key contributor of Product and Partnering organization, a Flagship Pioneering initiative focused on conceiving and developing transformative treatments for patients. We build a portfolio of novel therapeutics by harnessing Flagship’s scientific platforms and applying them to serious diseases beyond their current focus areas. Through this approach, we aim to bring the benefits of Flagship’s innovation to more patients, faster. 
 
This role sits at the intersection of science, strategy, and finance—supporting portfolio decision-making through rigorous analytics, financial modeling, and market evaluation. The successful candidate will combine deep biopharma industry knowledge with advanced financial modeling skills, particularly in valuation and forecasting of pharmaceutical products across therapeutic areas and development stages. The individual will collaborate across R&D, business development, finance, and commercial strategy teams to generate data-driven insights that inform portfolio and investment decisions. 
 

KEY RESPONSIBILITIES

Financial Modeling & Valuation 

• Develop robust, detailed financial models for Flagship’s therapeutic programs and platforms, including revenue forecasts, valuation analyses (DCF, NPV, rNPV), and scenario planning.
• Translate scientific, clinical, and operational assumptions into quantitative business models.
• Support capital allocation analyses and portfolio prioritization through rigorous sensitivity and risk-adjusted analyses.
• Maintain and improve financial models and forecasting frameworks as portfolio complexity increases. 

Market and Competitive Analytics 

• Conduct comprehensive market landscape analyses using both secondary sources and primary research (e.g., KOL interviews, surveys) to assess unmet needs, competitive dynamics, and market potential.
• Monitor key trends in relevant therapeutic areas and biopharma markets to inform portfolio strategy.
• Understand competitive positioning of ongoing and planned Pioneering Medicines programs.
• Summarize market and competitor insights into clear, concise reports for leadership review. 

Portfolio Strategy & Governance Support 

• Build and maintain portfolio analytics tools and frameworks to support resource planning, portfolio valuation, and scenario modeling.
• Prepare high-quality materials and analyses for internal governance and investment committee reviews, including portfolio summaries, risk assessments, and valuation comparisons.
• Ensure consistent use of financial and operational metrics across programs and functions.
• Benchmark portfolio and organizational performance against comparable biotech and pharma peers to identify key measures of success. 

Cross-Functional Collaboration 

• Partner closely with R&D, Competitive intelligence, Finance, Business Development, and Commercial Strategy teams to align scientific and business perspectives in portfolio analytics.
• Collaborate with data and insights teams to integrate forecasting models with relevant clinical and operational data systems.
• Serve as an analytical partner to program leads, helping teams understand value drivers, risks, and key decision points.
• Collaborate with Finance on annual LRP process and output 

Leadership & Influence 

• Lead cross-functional analytical initiatives.
• Proactively identify analytical or process improvements to enhance portfolio visibility and decision-making.
• Champion data-driven and enterprise-level thinking across Pioneering Medicines teams. 

Operational Excellence 

• Build scalable systems and dashboards to enable efficient portfolio tracking and forecasting.
• Drive standardization of assumptions, metrics, and templates across portfolio analyses.
• Complete ad hoc requests and deliver outputs with minimal oversight in a timely manner. 

PROFESSIONAL EXPERIENCE & QUALIFICATIONS

Education (one of the following combinations): 

• Ph.D. in a life science discipline (e.g., Biology, Biomedicine, Chemistry, Pharmacology) with at least 3 years of relevant industry or consulting experience.
• MBA with a strong quantitative or finance focus (e.g., healthcare management, finance, strategy) with at least 5 years of relevant experience.
• Master’s degree in life sciences, economics, finance, or a related field with at least 5 years of experience.
• Bachelor’s degree in life sciences, economics, finance, or a related field with at least 8 years of relevant experience. 

Experience: 

• Demonstrated expertise in financial modeling and valuation of pharmaceutical assets and portfolios, including revenue forecasting and risk-adjusted returns.
• Experience in biopharma investment banking, Big 4 advisory, life science strategy consulting, or corporate/business development in biotech or pharma.
• Proven ability to perform competitive analysis and market assessments across therapeutic areas.
• Familiarity with analytics and forecasting tools, such as advanced Excel modeling. Experience with Tableau, Power BI, or equivalent visualization platforms and portfolio management or valuation software (e.g., Planisware, Palantir) is a plus.
• Strong analytical, critical thinking, and problem-solving skills with the ability to synthesize complex data into actionable insights.
• Excellent written communication skills, including experience preparing executive-ready materials and analyses to support senior decision-making.
• Ability to work effectively in a cross-functional, fast-paced, and entrepreneurial environment, managing multiple priorities under tight deadlines.
• Collaborative team player with strong interpersonal skills and the ability to influence without authority. 

LOCATION:  Cambridge, MA

ABOUT FLAGSHIP PIONEERING:

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $148,000 - $203,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines’s good faith estimate as of the date of publication and may be modified in the future.

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