Associate Director, Clinical Site Budgets & Contracts

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company – existing at the intersection of machine learning, biological engineering, and medicine – pioneering Generative Biology™ to create breakthrough medicines where novel therapeutics are computationally generated, instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 million in funding, providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover, Massachusetts with 300+ employees.

The Role: 

The Associate Director, Clinical Site Budgets & Contracts is a strategic leader within Clinical Development responsible for developing global site budget strategies, negotiating investigator site budgets and agreements, and ensuring fair market value while maintaining clinical timelines and mitigating risk.

This role sits at the intersection of Clinical Operations, Finance, Legal, and external partners, driving scalable processes and tools to support global Phase 1–3 clinical programs. The Associate Director will lead cross-functional initiatives, build standardized budget infrastructure, and may manage direct and/or indirect reports across regions.

This is a highly visible role requiring strong strategic thinking, stakeholder influence, and enterprise-level decision-making consistent with Generate’s leadership principles.

Here's how you will contribute:

• Develop and maintain standardized global clinical site budget templates and negotiation playbooks.
• Lead global Phase 1–3 investigator site budget and contract negotiations within approved parameters.
• Ensure compliance with regulatory requirements and fair market value standards.
• Partner with CROs to oversee global site budget processes and drive consistency across programs.
• Proactively identify budget risks, escalate issues, and implement mitigation strategies to protect clinical timelines.
• Oversee contract and budget tracking systems, reporting metrics, and dashboard updates.
• Establish scalable tools and processes to improve efficiency and reduce administrative burden.
• Provide investigator grant budget forecasts and strategic input to Clinical Operations and Finance.
• Represent the function in cross-functional governance discussions and strategic planning initiatives.
• Liaise with legal department to support efficient clinical site contracts review, escalation, and approval parameters.
• Support contract signature and storage workstreams, and various ad hoc clinical and vendor contracts workstreams as required. 

Leadership Responsibilities:

• Drive results and accountability by setting clear performance expectations and using data-driven insights to manage budget performance and vendor outcomes.
• Build and develop high-performing, diverse, and collaborative teams, potentially managing direct and indirect reports across regions.
• Foster a culture of transparency, integrity, and continuous improvement in budget development and negotiation practices.
• Promote strategic thinking by aligning site budget strategy with broader clinical and enterprise objectives.
• Model adaptability and calculated risk-taking in negotiation strategy and vendor management.
• Practice transparent and courageous communication across internal and external stakeholders.

The Ideal Candidate will have:

• Bachelor’s degree in healthcare, business, life sciences, or related discipline (or equivalent experience).
• 10+ years of experience in clinical site contracting and budget negotiation within the pharmaceutical or biotech industry.
• Demonstrated global Phase 1–3 clinical site agreement and budget negotiation experience.
• Understanding of regulatory and compliance considerations related to site activation and contracting.
• Experience leading cross-functional initiatives in a global environment.
• Proven people management experience, including direct and/or virtual team leadership.
• Contract management expertise across multiple programs and timelines.

• Advanced negotiation and redlining skills with outstanding attention to detail.

• Advanced Excel skills for financial modeling and metrics tracking; strong PowerPoint skills for executive communication.
• Excellent written and verbal communication skills; ability to influence senior stakeholders.
• Ability to travel quarterly to corporate office.

Nice to Have:

• Experience with GrantPlan, Grants Manager, or similar grant management systems.
• Smartsheet experience.
• Advanced degree (MBA, MS, JD preferred but not required).
• Experience optimizing business models with strategic CRO partners.

Why Join Us

Generate:Biomedicines is pioneering Generative Biology™ to create breakthrough medicines by computationally generating novel therapeutics rather than discovering them through traditional approaches. Our machine learning-powered platform represents a fundamental shift in biotherapeutic development, with the potential to transform the lives of billions.

We are a collaborative, ambitious, and relentlessly curious team driven by impact. If you are energized by solving complex problems at global scale and building systems that accelerate clinical innovation, we would love to meet you.

Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

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