Senior Research Associate I/II, Discovery, Genome editing
Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.
We are seeking a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. The current role is for a Senior Research Associate to advance our ongoing efforts to develop therapeutics for neurodegenerative disorders . The candidate should have a passion for characterizing the CRISPR systems that advance our therapeutic programs. The role will work collaboratively across interdisciplinary teams, including protein engineers, process sciences, computational biologists, NGS, and disease experts. The candidate should bring experience in molecular biology, cell culture, and a passion for creating tools to meet the challenge of this new frontier in genetic medicine.
The candidate will have numerous opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a role of increasing responsibilities and the ability to publish highly impactful work in peer reviewed journals.
Key Responsibilities:
- Work collaboratively and cross-functionally with other teams at Scribe to execute on projects with established timelines.
- Plan, execute on in vitro and molecular biology assays. Analyze results and interpret data, to provide conclusions to support research goals.
- Develop and implement protocols for in vitro cell assays to support screening.
- Effectively communicate scientific plans and progress to stakeholders, verbally and in writing.
- Maintain rigorous data traceability.
- Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science
Required Skills and Background:
- A Bachelor’s and/or Masters in Neuroscience, Molecular & Cell biology, Bioengineering, Genetics, or related discipline with 3+ years (Msc) or 5+ years experience (Bsc) relevant experience.
- Hands-on experience analyzing DNA/RNAs methods or proteins (ELISA, qPCR, ddPCR, flow cytometry, western blot, and other techniques). Method development experience with ddPCR is highly valued.
- High level of proficiency in molecular biology techniques, including molecular cloning (gibson cloning, processing genomic DNA/RNA, and imaging related techniques (IHC/IF staining, confocal microscopy)
- Strong mammalian cell culture experience ( primary, immortalized cell lines). Direct experience with neuronal lines (iPSC-derived neurons or other) is a plus.
- Ability to work both independently and collaboratively in a fast-paced, interdisciplinary research team.
- Excellent prioritization and organization skills
Preferred Skills and Background:
- Competence with viral and non-viral based payload delivery modalities (AAV, Lentivirus, mRNA lipofection).
- Direct experience in the development of gene and/or cell therapy-based treatments for CNS/neuromuscular disorders
- Experience with high throughput or high content assays for screening is desirable.
- Familiarity with CRISPR-Cas gene editing systems
- Previous industry experience
