Senior Research Associate/Associate Scientist, Immunology

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?

The Company:

Quotient Therapeutics is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

Position Summary:

Quotient Therapeutics is seeking a Senior Research Associate/Associate Scientist with experience in immunology, molecular biology and early drug discovery. This position will contribute to the translational validation of discovery platform targets in mechanistic and disease-relevant pharmacological models.

The ideal candidate will be a talented, goal-oriented and highly motivated individual who will play a vital role in progressing the company’s early discovery projects in inflammatory and autoimmune diseases. They will have a strong background in developing complex immune assays with primary human cells and tissues designed to understand the molecular basis of disease states as well as drug mechanism of action.  The candidate must be comfortable working in and contributing to a diverse, highly dynamic, fast-paced and cross-functional team environment. Excellent communication skills, independence and open-mindedness are highly valued.

Responsibilities:

• Use insights from literature and experimental results to design, optimize and implement robust in vitro and in vivo experiments to validate target mechanisms and translational relevance to human disease
• Execute biochemical and cell-based assays using recombinant proteins, cell lines and primary cells isolated from blood and tissue to define drug mechanism of action
• Work both independently and in collaboration with cross-functional teams to ensure timely delivery of project milestones
• Utilize creativity and critical thinking skills to innovate, troubleshoot/optimize experiments and to interpret data to drive go/no go decisions
• Must display attention to detail, sense of urgency and ”outside the box” thinking

Qualifications:

• BS or MS in Immunology, Biochemistry, Molecular Biology, or a related discipline and 3+ years of industry experience for MS or 5+ years for BS industry experience in inflammation and immunology
• In depth understanding of cellular and molecular biology techniques including cell culture, transfection, viral transduction, CRISPR, western blots, qPCR, RNA-seq, immunofluorescence and flow cytometry.
• Experience with experimental design and strong proficiency in assay execution, troubleshooting, data analysis, and data interpretation
• Extensive hands-on experience of complex immunological assays using primary human blood and tissues, especially using primary human B and T cells
• Experience in FACS, cell culture, RT-qPCR, western blots and cell-based genetic manipulation (e.g., knockdown, knockout, overexpression) is a must. Proficiency with RNA-seq, cloning and image analysis are highly preferred
• Outstanding organizational, record keeping, collaboration communication skills
• Execution focused, team oriented, and highly motivated

Location: Cambridge, MA 

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.