Senior/Principal Scientist, LNP Formulation

The Company:

Mirai Bio is a Flagship-backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. Mirai’s platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

The Position:

Mirai Bio is seeking a highly skilled and motivated Senior/Principal Scientist to lead lipid nanoparticle (LNP) formulation development efforts. This individual will be responsible for the design and development of advanced LNP formulations for pre-clinical stage programs. The successful candidate will have deep expertise in LNP formulation and bioconjugation and will collaborate across multiple teams to optimize our LNP platform.

Key Responsibilities:

• Lead the design, development, and optimization of LNP formulations for nucleic acid delivery
• Optimize bioconjugation strategies to enhance LNP targeting and efficacy
• Develop integrated processes for production of advanced LNPs for early evaluations and further scale-up toward GMP
• Manage collaborations with internal and external partners, ensuring stakeholder alignment and delivering against tight timelines
• Ensure adequate resources (materials, equipment, and personnel) are available to meet production schedule and study timelines
• Collaborate with cross-functional teams to improve LNP function and efficacy
• Prepare and present findings to internal and external stakeholders, including executive leadership and collaborators.

Qualifications:

• PhD in a life sciences or engineering discipline with 5+ years of experience in nanoparticle formulation and/or drug delivery
• Extensive experience in the formulation, development, and characterization of LNPs, liposomes, polymeric nanoparticles, or similar
• Hands on bioconjugation experience
• Strong knowledge of process development, manufacturing, and scale-up
• A strong team player with the ability to work both independently and on cross-functional teams in a fast-paced, entrepreneurial environment
• Highly self-motivated and comfortable delivering against challenging commitments
• Excellent organizational and communication skills

About Flagship

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.