Synthego is enabling genome engineering at scale with a blend of scientific instrumentation, industrial automation, and data science. Our team of scientists and engineers are putting multidisciplinary fields together to solve problems that no one field can tackle alone.
We are searching for motivated, enthusiastic, and hands-on individuals interested in advancing science through the manufacturing of our CRISPR regulated products. As a Senior Lab Associate at Synthego, you will join our Clinical operations team and have direct responsibility for the synthesis and purification of our sgRNA products in the INDe and GMP factories. This role requires a strong attention to detail, a desire to learn and adapt to new processes, and familiarity with safe laboratory practices. This role will combine hands-on laboratory protocols with advanced automation to ensure the timely delivery of high quality products to our customers.
Available Shift & Training Schedule:
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Shift: Morning Shift (6:30am-3:00pm), Monday - Friday
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Training: Training will take up to 3 months. During the training period you may be asked to temporarily move to a different shift time due to staffing and training needs. After training is complete, you will work the hours/days of the week you were hired for.
What You'll Do:
- Operate and verify in the synthesis, purification, and fill/finish operations for clinical grade oligonucleotides by following established SOP’s
- Actively contribute to the optimization of laboratory protocols and workflows, applying continuous improvement methodologies to enhance operational efficiency.
- Ensure all batch production records and protocols are executed to the highest compliance standards, proactively identifying and resolving potential issues.
- Lead efforts to capture and analyze production data, ensuring it meets internal requirements
- Collaborate with Supply chain, Quality Assurance, Warehouse, and other cross-functional teams to meet deadlines.
- Safely handle and manage chemical solutions, with a deep understanding of the chemistry involved
- Operate complex lab equipment systems to manage product formulation through an automated workflow
- Train other operators in laboratory procedures
- Author and maintain work instructions (WIs) and standard operating procedures (SOPs)
- Write and perform investigation for non-conformance reports (NCRs), implement corrective actions, and prevent future occurrences.
- Ensure laboratory products and supplies are maintained and stocked
About You:
- Bachelor’s degree in chemistry or a related field, with minimum of 3 years of industry experience in a GMP or GLP regulated environment.
- Experience working in a regulated manufacturing environment, with an understanding of compliance requirements and quality management systems.
- Proficient in operating and troubleshooting laboratory equipment with the ability to resolve complex technical issues independently.
- Strong understanding of aseptic techniques and cross-contamination controls, with experience working in sterile environments for fill and finish operations as a plus.
- Demonstrates strong analytical and critical thinking skills, with the ability to anticipate and resolve issues before they impact operations.
- Strong desire to work in a fast-paced, collaborative startup environment
- Demonstrates strong interpersonal skills, as well as a strong commitment to quality
- Demonstrates ability to work independently and as part of a team, to meet departmental goals
- Must be able to lift/move up to 25 pounds
- Must be able to sit and/or stand for extended periods up to four (4) hours at a time
Nice to Haves:
- Experience training others in laboratory techniques and processes
- Expertise in aseptic technique and working in sterile environments
- Experience working with oligonucleotides, particularly in a production or GMP setting
- Experience writing Non-Conformance Reports (NCRs)
- Experience working on continuous improvements project
About Us
Synthego is a genome engineering company that enables the acceleration of life science research and development in the pursuit of improved human health.
Based on a foundation of engineering and chemistry, Synthego leverages automation and machine learning to synthesize high-quality CRISPR reagents for science at scale. Synthego’s mission is to enable agile life science research and development from discovery through clinical trials by providing scientists with comprehensive CRISPR solutions for each phase coupled with full technical and regulatory support from industry-leading experts.
With its technologies cited in hundreds of peer-reviewed publications and utilized by thousands of commercial and academic researchers and therapeutic drug developers, Synthego is at the forefront of innovation, enabling the next generation of medicines by delivering genome editing at an unprecedented scale.
