Principal Scientist, Medicinal Chemistry

What if… you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?

Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value. To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12^th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

The Company:

Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.

Position Summary

Quotient Tx is seeking a talented and highly motivated Principal Scientist, Medicinal Chemistry with relevant drug discovery experience to join our team.  This is an exciting opportunity to design and execute medicinal chemistry strategies that will support biology validation and drug discovery from hit finding to lead generation, lead optimization and candidate selection.  The successful candidate will work closely with Quotient’s Leadership Team and scientists to rapidly advance drug discovery programs to IND and early clinical studies. They will be comfortable working in and contributing to a highly dynamic and cross-functional team environment. The ideal candidate must be independent, open-minded, goal-oriented, have excellent communication skills and work in a fast-paced entrepreneurial environment.

Key Responsibilities

• Discover and advance novel chemical entities (small molecules, protacs, molecular glues) into clinical development
• Define, implement, and execute on medicinal chemistry strategies from hit ID to lead generation, lead optimization and candidate selection
• Provide strategic, scientific, and managerial leadership to external CRO med chem teams
• Serve as project and chemistry lead for drug discovery programs
• Collaborate with the IP team to create and execute strategy to establish, protect and expand intellectual property
• Communicate, collaborate, and coordinate effectively within cross-functional teams
• Effectively present and communicate research findings at internal meetings and external scientific conferences

Job Qualifications

• Ph.D. in Organic Chemistry or Medicinal Chemistry with a minimum of 10+ years of relevant drug discovery experience in the biotech/pharmaceutical industry
• Experienced in all aspects of medicinal chemistry including use of tool/probe compounds, hit ID and follow-up, hit-to-lead chemistry, and lead optimization to candidate selection
• Broad background in all aspects of drug discovery, including SBDD, physicochemical property-driven optimization (MPO) and computational chemistry
• Working knowledge of structural biology, ADME/PK, in vitro assays, and in vivo pharmacology
• Experience in managing and building strong relationships with chemistry CROs
• Demonstrated success in leading medicinal chemistry and projects teams to deliver high quality compounds into development
• Experience in oligonucleotide drug discovery is a plus
• Track record of delivering on project and company goals
• Ability to accommodate to rapidly changing priorities and deadlines
• Excellent communication and project leadership skills and ability to work effectively in a cross-functional team setting
• Proven track record for striving for a high level of innovation and scientific excellence

Location: Cambridge, MA 

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.