Principal Scientist, Innovation

Company Summary 

What if…you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies in order to transform health care and sustainability? 

Prologue Medicines is dedicated to transforming drug discovery by leveraging deep biological insights and cutting-edge scientific innovations. Our mission is to deliver breakthrough therapies that address critical unmet medical needs. As part of our dynamic and collaborative team, you will have the opportunity to impact human health on a global scale. 

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com. 

Position Overview: 

We are seeking a highly motivated and creative scientist to expand the horizons of our DELVE platform which is designed to unlock the therapeutic potential of the viral proteome. This role is ideal for a candidate who is passionate about pushing the boundaries of scientific innovation to unlock novel approaches to leverage and develop the potential of evolutionary optimized proteins. With a focus on viral proteins, the candidate will be responsible for developing and driving the strategy for continued innovation and expansion of Prologue’s DELVE platform. Your work will involve exploring their mechanisms, interactions, and potential applications in regulating human physiology. Further you will evaluate and develop delivery platforms to achieve optimal subcellular and tissue specific localization. Finally, you will collaborate closely with a cross-disciplinary team of scientists and researchers to design, conduct, and analyze experiments aimed at providing ‘Proof-of Concept’ data that demonstrate the therapeutic potential of viral proteins in diverse in vitro and in vivo disease models.

Key Responsibilities: 

• Develop a strategic plan to expand the discovery potential of Prologue’s platform and therapeutic application of viral protein in diverse diseases.
• Lead research projects to explore the therapeutic potential of viral proteins in various diseases.
• Design and execute laboratory experiments and analyze data to evaluate hypotheses and drive project advancement.
• Stay abreast of the latest scientific advances in life science, proteomics and drug delivery and apply cutting-edge techniques and methodologies in your research.
• Collaborate with computational biologists to analyze proteomic data and predict protein interactions and functions.
• Write research papers, reports, and present findings at scientific conferences and to non-scientific stakeholders.
• Work with the intellectual property team to patent viable discoveries.
• Mentor junior scientists and technicians in laboratory techniques and scientific theory. 

Qualifications: 

• PhD. in Molecular Biology, Biochemistry, Virology, Immunology or a related field, with a strong background in protein science or biotechnology.
• Minimum of 12+ years postdoctoral experience in a research environment
• 6+ years of industry experience with a track record of developing innovative platforms or products exemplified by top-tier publications or patents.
• Experience in gene or protein delivery using emerging modalities such as lentivirus, LNPs or AAVs.
• Excellent problem-solving skills, with the ability to think creatively and outside the box.
• Strong communication and interpersonal skills, with the ability to work collaboratively in a team-oriented environment.
• Experience in CRISPR, RNAi technologies, and other gene-editing tools is a plus. 

Preferred Qualifications: 

• Knowledge in autoimmune diseases, oncology, or infectious diseases.
• Experience in bioinformatics and computational biology tools.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. 

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.