Pioneering Medicines: Scientist / Senior Scientist Contractor, Mechanism of Action - Metabolism

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. 

About Flagship Pioneering:

Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.  

Position Summary:

We are seeking an Associate Scientist/Scientist Contractor to be responsible for developing and performing in vitro and ex vivo studies for the mechanism of action and efficacy of novel biological and/or small molecule therapeutic agents, including nucleic acid-based approaches, to support drug discovery efforts across multiple programs from target validation to human translation.

The ideal candidate will possess expertise in cell-based assays using both cell lines and primary cells from rodent, non-human primate (NHP), and human sources. Previous in vitro experience with primary cells (e.g., adipocytes & hepatocytes) is highly desired. The position requires the ability to work in a fast-paced environment on multiple tasks, quickly learn new techniques, organize tasks efficiently, and maintain accurate records. Strong interpersonal skills to collaborate effectively with scientific colleagues in a team-oriented environment are essential.

This role is a 12-month contract. Pioneering Medicines 3rd party agency will be hiring for this position. Employees under this position with be working at Pioneering Medicines Cambridge, MA location as a contractor with the possibility to convert to a full-time Pioneering Medicines employee based on performance and other criteria in the future.

Key Responsibilities:

• Plan, design, and execute wet lab experiments for evaluating therapeutic targets in drug development; previous experience in metabolism is a plus.
• Work independently or as part of a collaborative team to support research activities and project goals.
• Adapt to a fast-paced environment and remain flexible in response to changes.
• Analyze data independently and communicate results, conclusions, and next steps to scientific leads.
• Conduct laboratory-based assays in BSL2/BSL2+ environments.
• Maintain excellent experimental records, including writing experimental protocols and managing an electronic lab notebook.
• Operate and maintain relevant equipment.

Qualifications, Skills, and Experience:

• Master’s with a minimum of 2-5 years of experience in an academic setting or PhD degree in biology; biotech or industry experience is preferred.
• Prior experience with in vitro cell-based pharmacology assays using human or rodent primary cells.
• Proficient in assay development for testing compounds across different modalities.
• Hands-on experience with cell-based and molecular biology assays, such as flow cytometry, immunoblotting, ELISA/MSD, tissue processing, protein extraction and quantification, RNA isolation, and qPCR.