What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?
Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments.
About Flagship Pioneering:
Flagship Pioneering conceives, creates, resources, and develops first-in-category life science platform companies to transform human health and sustainability. Since its founding in 2000, the firm has originated and fostered the development of more than 100 scientific ventures, resulting in over $34 billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents.
Position Summary:
Pioneering Medicines is seeking a creative, motivated, and highly collaborative Scientist to join the biology-pharmacology team. The ideal candidate should have a passion for science and medicine with prior hands-on experience in drug discovery or metabolic disease research. The incumbent will support the screening, characterization, and mechanism of action studies for various drug candidates like small molecules and/or nucleic acid-based therapeutics.
The ideal candidate needs to have an understanding of in vitro & ex vivo biology & pharmacology, with a track record of defining critical decision-driving experiments and developing robust assays across therapeutic areas related to metabolic diseases driving programs to go/no go decision points. They will show the ability to excel in a fast-collaborative multidisciplinary environment and have strong written and oral communication skills. We are looking for a team player who embraces our core values of putting people and patients first, working hard and strategically in a professional R&D environment that encourages growth and learning.
Key Responsibilities:
- Act as a functional lead for designated project(s) to define, develop, and implement appropriate assays to support PM’s pipeline
- Develop cell-based assays using human & rodent cell types like adipocytes, myocytes, peripheral blood cells, primary cells, iPSCs and/or organoids, as well as ex vivo experiments to support in vitro pharmacology and translational studies.
- Work with colleagues of the in vitro, in vivo, and translational teams to support PM’s research projects and daily laboratory operations.
- Always value and contribute to teamwork across internal functional units and with external collaborators to advance programs from research to the clinic.
Basic Qualifications:
- Fresh PhD or MSc degree with 5+ years of research experience in biology or a related scientific area. Industry experience preferred.
- Extensive training in cell biology, biochemistry, and molecular biology.
Other Qualifications:
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- Extensive experience with cell culture including primary & immortalized mammalian cells or iPSC-derived cell systems is essential.
- Hands-on experience in in vitro assays with an emphasis on metabolism is a must.
- Relevant industrial experience is a plus.
- Familiarity with genetic-based approaches such as CRISPR and RNA interference; and general laboratory techniques including qPCR, Western blotting, ELISA, MSD, flow cytometry, confocal-microscopy, and metabolic assays.
- Working knowledge of in vitro pharmacology, including handling of candidate compounds, dose response, potency, and efficacy studies.
- Understanding of general drug discovery process, from target identification and validation through regulatory filing.
- Prior experience working with cross disciplinary internal and external scientific teams (e.g., CROs, academic collaborators) is a plus
- Track record of successful research outcomes especially data analysis and summarization, exemplified by publications, presentations, and/or contributions to drug discovery programs
- Ability to clearly communicate scientific data with the team and stakeholders, and perform detailed documentation of experimental results via ELN (Electronic Lab Notebook)
- Proficient in scientific software (e.g., GraphPad Prism, FlowJo) is required.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
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