Pioneering Medicines Director / Senior Director, In Vitro Pharmacology

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines is dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship’s multiple bioplatforms and Flagship’s proprietary innovation process. By harnessing the power of Flagship’s first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied more broadly, thereby delivering benefits to more patients, sooner.
With a highly experienced drug development team and access to the wide ecosystem of Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners and advance these assets through to significant value inflection. Pioneering Medicines currently has 11 programs ongoing with plans to have more than 15 programs in 2024. Pioneering Medicines works with external strategic partners including Novo Nordisk, Pfizer, and the Cystic Fibrosis Foundation and continues to engage in discussions on potential partnerships.

Position Summary:

Pioneering Medicines is seeking a highly motivated and strategic In Vitro Pharmacology leader to support a growing portfolio of assets. This key leadership role will require an individual to direct and oversee in vitro pharmacology efforts, participating in drug discovery and early development activities. The role will involve functional accountability to support assets across a diverse range of modalities and therapeutic areas, including inflammation and metabolic diseases. The candidate will work in cross-functional teams leading and supporting the activities, delivering research leadership, and managing scientists. The successful candidate is expected to proactively build and maintain strong collaborations with Flagship Pioneering platform companies and large pharma partners. We are seeking individuals who are analytical, goal-oriented, and timeline-sensitive, while maintaining the highest of scientific and ethical standards. Strong communication skills and comfort working in a dynamic and cross-functional team environment are required.

Responsibilities:

• Support projects across diverse therapeutic areas/modalities including inflammation and metabolic therapeutic areas
• Serve as a Research Project Leader to develop research strategy and drive execution of drug discovery projects
• Identify and implement preclinical cell-based models that reflect patient pathology and develop assays to support in vitro characterization of lead small molecules, biologics, and genetic modalities
• Develop  in vitro pharmacology plans and budgets to progress lead molecules from hit-to-lead to DC and IND/CTA
• Lead scientific discussions with Flagship Platform companies and external pharmaceutical partners
• Lead a team of PhD and non-PhD scientists, including managers
• This position is on-site/hybrid in Cambridge, MA

Required Qualifications & Experience

• Ph.D., in Biology, Biochemistry or related field
• 12+ years of relevant pharmaceutical/biotechnology experience
• Extensive experience in assay development and proficiency in drug discovery and development, including delivering data and documentation supporting IND/CTA regulatory filings
• Proven leadership and excellent mentorship skills, with experience in managing a team and leading programmatic matrix teams
• Scientific experience working in inflammation or metabolic drug discovery and development programs
• Ability and interest to work across multiple therapeutic areas and modalities
• Ability to effectively communicate complex scientific concepts and data to both scientific and non-scientific colleagues

Preferred Qualifications

• Experience performing scientific due diligence on assets and/or platform biotechs
• Experience working on cross-industry collaborations 

About Flagship Pioneering:

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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