Pioneering Medicines Director / Senior Director , Cardiovascular Heart Failure

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines, an initiative of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. 

About Flagship Pioneering:

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.     

What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.   

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. 

 Position Summary:

Pioneering Medicines is seeking a highly motivated experienced, innovative leader with deep subject matter expertise & scientific acumen in cardiovascular/cardiometabolic disease drug discovery (CVD/CVMD). In this role, you will lead a research team focused on developing novel therapies. You will work across several functional teams to support all aspects of drug discovery, preclinical research to early clinical development  to progress a pipeline of innovative therapies to address serious cardiovascular, cardiometabolic unmet needs.

This role will be based at our Cambridge, MA location. We have a hybrid model and onsite presence 3 times per week is required.

Responsibilities:

• Facilitate creative thinking to identify novel targets through target identification/validation, lead optimization, preclinical support of the research programs in cardiovascular/cardiometabolic areas
• Set strategies for identifying novel pathways and mechanisms within cardiovascular, cardiometabolic fields
• Work on mechanistic studies for proof of concept and target validation through preclinical and early clinical
• Develop biomarker strategy and translational studies
• Participate in external partnerships, consultation, and collaboration efforts with CROs to advance pipeline programs in cardiovascular and cardiometabolic fields.
• Lead world-class, cutting-edge research effort in cardiovascular and cardiometabolic areas that promotes collaborative culture both internally and externally, with a focus on designing mechanistic studies with a goal to facilitate robust, efficient decision-making to drive results
• Utilize strong communication skills to influence and ensure our flagship pioneering medicines ecosystem and external partnerships align

Required Qualifications:

• Ph.D or M.D/Ph.D in Cardiovascular, Cardiometabolic , Cardio-renal or related areas
• Outstanding track record in academia with deep scientific experience & translation related to drug development 
• Subject matter expertise in both invitro assays, 3D organoids, and in vivo models, in cardiovascular and cardiometabolic physiology and pathophysiology.
• Record of accomplishment of initiating programs in discovery setting and driving to the clinic 
• Deep understanding of cardiovascular, and cardiometabolic biology
• Experience building strong teams
• Ability to motivate, influence, develop/mentor others, leading by example through scientific /technical expertise
• Experience presenting clear and compelling scientific and business cases

Preferred Qualifications:

• 10+ years of industry experience
• Experience leading programs from discovery to early clinical phase
• Experience leading drug discovery and development in cardiovascular/cardiometabolic areas in pharma/biotech industries
• Experience working with small molecules & antibodies with appreciation for multi-modalities approach to target novel challenging targets
• Hands on experience in cardiovascular and cardiometabolic progressing innovative therapies

Benefits Include:

• Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid flexible time off, 401k retirement plan, disability and life insurance, mental health program via Calm, backup care for children/senior and fully covered parking/commuter benefits.
• A dynamic work environment with entrepreneurial spirit and highly interdisciplinary, talented, and collaborative team.
• Opportunities to work with Flagship scientific platforms/portfolios and create novel treatment options that benefit more patients sooner.
• Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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