Off-Target Biology Co-Op

Company Overview: 

Beam Therapeutics is committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.

Position Overview:

Beam is looking for a highly energetic and motivated co-op student to join our Off-target Biology Team from January through June 2025. This co-op student will be responsible for performing off-target discovery and validation experiments using a variety of gene editing tools, including base editors. This platform focused position will play a key role in identifying and establishing novel technologies related to profiling off-target and unintended gene editing outcomes, while also performing and optimizing methodologies for existing tools to further enhance our understanding of gene editing outcomes.

Responsibilities:

• Execute tissue culture and gene editing experiments in cell lines.
• Support the profiling of gene editing outcomes using next generation sequencing (NGS)-based techniques.
• Perform off-target editing discovery and validation assays.
• Maintain detailed documentation of experiments in an ELN system
• Collaborate and communicate effectively across a multidisciplinary team.

Qualifications:

• Pursuing a BS or MS in biological sciences or a related field (Bioengineering, Biochemistry/Biophysics, Cell Biology/Molecular Biology) with at least 1 year of relevant laboratory experience.
• Prior experience with tissue culture work is desirable.  
• Knowledge of genomics and molecular biology is highly desirable.
• Proficient in Excel, PowerPoint, and data analysis.
• Experience maintaining a lab notebook and following written protocols.
• Detail-oriented and organized, with excellent communication skills and teamwork.
• Motivated to learn new and exciting practices at the cutting-edge of gene editing!