Head of Translational

The Company:

Mirai Bio is a Flagship-backed, privately held biotechnology company on a mission to transform the current approach to information molecule therapeutics to unlock their full therapeutic potential. In recent years, we have begun to experience the power of information molecules in treating historically undruggable diseases and in designing therapies with unprecedented turnaround times. Mirai’s platform integrates nanoparticle development with world-class informatics technologies and a novel pipeline of experimentation and discovery to drive a new generation of highly effective, therapeutically relevant information molecule therapies. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

The Position:

Mirai Bio is seeking a highly talented individual to lead its Translational Biology Group and manage multiple research programs as part of FL85’s Platform Group where they will identify, prioritize, and provide innovative solutions to challenges posed by delivery of nucleic acid therapeutics. They will work cross-functionally to direct and oversee discovery research and therapeutic candidate development programs to enable Mirai’s next generation genomic medicines. The successful candidate will implement strategies to overcome limitations of current nucleic acid delivery approaches and will have a strong understanding of targeted information molecule delivery and relevant in vitro and in vivo models. A robust background in immunology, pre-clinical pharmacology and in vivo delivery modalities is required. As the Head of Translational Biology, the successful candidate will support development of novel non-viral delivery capabilities and key responsibilities will include:

• Directing and overseeing discovery programs covering in vitro and in vivo proof-of -concept studies in small and large animal models in support of developing innovative non-viral vectors with cell-specific tropism and/or enhanced functional delivery properties.
• Delivering rigorous workflows, including generation and implementation of ideas to facilitate novel non-viral delivery approaches with other parts of the organization and external collaborators.
• Designing and troubleshooting experiments derived from industry experience and literature review.
• Initiating and overseeing collaborations with industry partners.
• Establishing and managing timelines to ensure projects are completed according to schedule.
• Setting project priorities, planning workload, and managing resource and personnel scheduling.
• Ensuring group goals are met and are aligned with broader organizational objectives.
• Preparing study materials and presenting scientific presentations at internal and external meetings including to senior leadership.
• Training, developing, and providing leadership to a team of Scientists and Research Associates.

Education and Experience Requirements:

• Ph.D. in Immunology, Biochemistry, Pharmacology, or related field
• Typically has 8+ years of relevant work experience related to in vivo delivery in a biopharmaceutical setting
• Subject matter expert in the fields of pharmacology and in vivo delivery with hands-on research application experience related to delivery of nucleic acid therapeutics – experience with immunology and biodistribution studies is a plus
• Prior management experience is required
• Proven ability to work independently and cross-functionally with highly skilled teams in a fast-paced, entrepreneurial, and technical environment
• Experience managing CROs and external collaborations
• Strong organizational and problem-solving skills
• Motivated, curious, proactive and comfortable working with highly technical projects and bringing their technical expertise to problem solving with others
• Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner
• Comfortable delivering against challenging commitments and timelines

About Flagship

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.