An exciting opportunity is available for an enthusiastic, self-motivated scientist to join our DMPK lab team in our Cambridge Laboratories. We are a small group addressing a wide range of DMPK assays, ranging from in-vitro ADME assays to PK bioanalysis and PK parameter generation, including the design, execution, analysis, interpretation and high-quality reporting of these experiments. We have modern instrumentation, automated liquid handlers coupled with Watson PK LIMS, Dotmatics electronic laboratory notebook and data warehouse to facilitate experiment management and reporting.
In addition, as a part of continuous personal development and learning, there will be opportunities for you to gain further understanding of the DMPK discipline and contribute to work supporting our drug discovery project teams.
Responsibilities
- You will perform discovery experiments to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of candidate drug molecules.
- You will perform experiments from start to finish, including the running the assays, analysis, interpretation and reporting of discovery DMPK data generated in your experiments.
- Where appropriate, you will assist with experimental design and troubleshooting.
- Conduct data processing, as well as data review and QC checking.
- Depending on skills and experience you will be encouraged to critically evaluate our processes and contribute to assay development, including the experimental design, execution, data reduction and interpretation.
We are looking for:
- B.Sc., M.Sc. and/or Ph.D. in pharmaceutical sciences, Chemistry, Biochemistry or related disciplines with some knowledge of absorption, distribution, drug metabolism and pharmacokinetics.
- Outstanding written and verbal communication skills.
- Ability to multitask and prioritise workload, with excellent attention to detail.
- Experience using balances, pipettes, pH meters, & centrifuges; with the ability to do the calculations required to prepare stock solutions and basic laboratory reagents.
- Computing skills, including word processing and use of spreadsheets (e.g. Microsoft Office packages and Google G-suite).
Nice to have:
- Proficiency in operating and trouble-shooting liquid chromatography-tandem mass spectrometry systems (LC-MS/MS) would be an advantage, although we have robust workflows in place and full training will be provided.
- Some biotech and/or pharmaceutical industry experience in discovery DMPK.
