Are you a highly motivated nonclinical safety scientist with extensive experience in the pharmaceutical industry? If so, then we want to hear from you. We are looking for a talented nonclinical safety expert to head up our Nonclinical Safety department at Director grade, providing significant support to our portfolio of small molecule drug discovery programs.
Based at our London or Cambridge offices and with flexible working arrangements, you will have accountability for all nonclinical safety activities across the portfolio, defining the safety strategy to progress programs through drug discovery and development.
Responsibilities
- Lead, mentor, and manage a small team of nonclinical safety scientists
- Represent safety pharmacology on the drug discovery leadership team
- Provide expert guidance to project teams, taking accountability for decision making and defining industry-leading approaches to address safety issues at all stages of development from target ID to preclinical development
- Design and implement robust toxicology studies to assess the safety profile of drug candidates, ensuring compliance with regulatory guidelines
- Define comprehensive and actionable safety derisking strategies from target ID onwards, integrating target safety assessments, in silico toxicology and the latest in vitro toxicology methods
- Collaborate with cross-functional teams, contributing to the overall drug discovery and development strategy
- Provide nonclinical safety expertise to define indication specific regulatory strategy and take responsibility for regulatory submission authoring
- Keep up to date with industry trends, regulatory requirements, and advancements in nonclinical safety and drug development
We are looking for:
- PhD in toxicology, pharmacology, biochemistry or a related discipline, or industry equivalent
- 10+ years’ experience working in the pharmaceutical industry with a minimum of 5 years in the field of toxicology/nonclinical safety
- Proven leadership experience, both in managing teams and projects
- Detailed knowledge of global regulatory guidelines and requirements relating to preclinical safety activities
- Excellent communication, collaboration, and organisational skills
- Experience in early discovery safety, including target safety assessments, in silico toxicology, and target de-risking strategies
- A track record of contributing to successful drug discovery and development programs, including regulatory submissions
