Associate Scientist / Scientist, In Vivo Pharmacology

Company Summary: 

Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing multi-specific medicines that direct a wide range of therapeutic molecules to specific cells and biological contexts (www.Ampersand.bio).  Ampersand was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created.  With a strong emphasis on innovation, Ampersand cultivates a highly dynamic and entrepreneurial environment.

Position Summary:

Ampersand is seeking a highly motivated and detail-oriented Associate Scientist/Scientist I to join our dynamic In Vivo Pharmacology team, leading projects in discovery and pre-clinical development for antibodies and related protein therapeutics. The successful candidate will play a key role in designing, executing, and analyzing in vivo studies to evaluate therapeutic modalities with the aim of nominating development candidates, and supporting preclinical development and translational science of these molecules through to IND and beyond. Compensation and grade will be adjusted to the experience level of the applicant.

As a member of our team, you will be responsible for designing and executing experiments to understand the activity, mechanism of action, and therapeutic potential of early-stage biologics. This role offers the opportunity to work in a dynamic, fast-paced, entrepreneurial environment, where you will have the chance to work independently as well as collaboratively within a highly integrated team. This is an on-site role in South Boston.

Key Responsibilities included but not limited to:

• Planning, execution, and analysis of in vivo projects to evaluate therapeutic modalities and strategies including pharmacokinetic/pharmacodynamic, biodistribution, and efficacy studies.
• Conducting ex vivo wet lab experiments to analyze gene expression and protein levels,
• Ability to work independently and as part of a collaborative team to design, plan and execute experiments, and manage outcomes to support research activities, project goals, and platform development.
• Creative and strategic contributions to the discussions, designs, and implementation of in vivo and ex vivo
• Managing relationships with external research facilities.
• Reporting results to the scientific team and management.
• Critical data analysis, attention to detail, and troubleshooting abilities.
• Maintaining an organized and up-to-date electronic lab notebook.
• Writing, updating, and maintain high-quality experimental protocols.

What you bring: (Qualification, skills, and experience): 

• PhD or MS degree with 2-5+ years of relevant experience in vivo and ex vivo lab experiments in the pharma or biotech industry.
• Experience conducting in vivo studies with small animal models and capable of performing research activities to support our platform.
• Proficiency in dosing via multiple routes of administration including IV, SC, IP, oral (PO), intramuscular (IM) as well as expertise with blood collection (via tail vein, cardiac bleed, cheek bleed, saphenous vein), dissection techniques, and necropsies.
• Hands-on experience with ELISAs, tissue processing, protein extraction and quantification, RNA isolation, qRT-PCR.
• Experience with flow cytometry and IVIS.
• Strong interpersonal skills including verbal and written communication.
• Highly adaptable, and flexible to change in a fast-paced, dynamic, cross-functional, and team-oriented environment.
• Strong communication, organization, and documentation skills.
• Ability to prioritize and work across multiple projects to meet the deadlines. 
• Experience with genetically engineered mouse models is desirable.
• Experience with immunohistochemistry, immunofluorescence, spatial transcriptomics, etc., is also desirable.

What We Will Offer You:

• A dynamic work environment and highly interdisciplinary, talented, and collaborative team.
• Participation in an unprecedented opportunity to significantly impact the quality of life of patients by developing a targeted approach to delivering therapeutic molecules.
• Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.