About the Role >>> Associate Director, Medicinal Chemistry 

As Associate Director of Medicinal Chemistry reporting to the Senior Director of Medicinal Chemistry, you will provide leadership to the internal medicinal chemistry team and scientific oversight of external resources involved in the design and synthesis of novel small molecule drug candidates. You will lead the medicinal chemistry function within multidisciplinary project teams to help advance drug discovery projects from inception to the clinic in support of our mission to deliver novel medicines to the cancer patients who need them.

This role is based out of our San Francisco laboratory and may require international travel 1-2 times per year. 

Your work will primarily encompass:

• Advancing novel small molecule hits and lead compounds into clinical candidates by leveraging experience in fragment-based ligand design, structure-based drug design, and/or multi-parameter lead optimization. 
• Performing hit-to-lead and lead optimization by designing and managing the synthesis of novel small molecules.
• Providing leadership and mentorship to a team of internal chemists and effectively communicating scientific strategy, project goals, and individual expectations.
• Managing external chemistry resources by designing synthetic strategies, prioritizing targets, and proposing creative solutions to chemistry problems. 

 And will also include: 

• Leading the medicinal chemistry function within multidisciplinary project teams.
• Communicating project results and progress to key internal and external stakeholders.
• Developing internal talent by providing positive mentorship while fostering a culture of collegiality, accountability, and scientific rigor.
• Partnering with internal colleagues and external collaborators in cross-functional teams to ensure efficient progression of new compounds through assay workflows.
• Writing scientific manuscripts/posters in support of Olema’s publication strategy
• Active participation in laboratory safety and environmental initiatives. 

Ideal Candidate Profile  >>>  

A love of challenging, important work. We are a pragmatic team, driven to imagine and develop meaningful therapies for improving lives. All employees within our company play a unique and crucial role in our success, both in accomplishing our mission and building a positive company culture. As such, we are looking for someone with the right combination of knowledge, experience, and attributes for this role. 

Knowledge: 

• Ph.D. in Organic or Medicinal Chemistry. 
• Expert synthetic and medicinal chemistry skills with a working knowledge of structure-based drug design as demonstrated by publications and patents.
• Deep knowledge of modern medicinal chemistry strategies for the optimization of physicochemical, biochemical and ADME properties. 

Experience: 

• 10+ years as a medicinal chemist in the pharmaceutical or biotechnology industry. 
• 3+ years independently managing external medicinal chemistry FTEs.
• At least 1 year as a functional lead within a multidisciplinary project team.
• Prior experience managing internal direct reports with a track record of mentoring junior staff and facilitating professional development.
• Experience using modeling software such as Maestro or MOE and using cheminformatics tools.
• Preferred: prior experience working on oncology targets and familiarity with PROTAC/molecular glue degrader and/or covalent inhibitor modalities 

Attributes:  

• Have impeccable professional ethics, integrity, and judgment. 
• Self-motivated and enthusiastic; fast learner who can identify the core project challenges and expeditiously change course as required in a fast-paced organization.  
• Teamwork and collaboration; balances team and individual responsibilities; gives and welcomes feedback; puts success of team above own interests; supports everyone's efforts to succeed; shares expertise with others.
• Be a “difference maker” in terms of one’s professionalism and contributions.
• Strong verbal and written communication skills to effectively share information with wide ranging internal and external audiences. 

The base pay range for this position is expected to be $193,000 -$206,000 annually, however the base pay offered may vary depending on location, market, job related knowledge, skills and capabilities, and experience. The total compensation package for this position also includes equity, bonus, and benefits.

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