Who we are:
Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X or LinkedIn.
How we work:
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PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
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COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
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BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.
How you’ll contribute:
The Associate Director, Clinical Pharmacology position will support a rapidly expanding clinical portfolio of promising TPD therapeutics. Currently there are several programs in phase 1 development and an active preclinical pipeline that is expected to produce additional new clinical programs annually. The candidate in this key position will be responsible for clinical PKPD, clinical pharmacology strategic and tactical aspects on project teams. In this role, the candidate is expected to have a strong regulatory and scientific foundation pertaining to drug development. The candidate is expected to conduct PK/PD analyses to guide decision-making on the project teams. Represent PK and provide PKPD support and guidance to clinical stage project teams.
- Lead the analysis, interpretation, integration and reporting of clinical pharmacokinetic & pharmacodynamic data. Conduct PK/PD analyses to guide development decisions on project teams.
- Conduct model-based analysis to guide dose escalation and dose selection in ongoing clinical studies.
- Develop an understanding of the relationship between clinical data and preclinical findings to inform individual development programs as well as broader technology platform research initiatives.
- Provide PKPD input for regulatory submissions such as briefing documents, IND, CTA and NDA.
- Design and oversee the conduct of clinical pharmacology studies (either standalone or within broader clinical trials) to generate high quality and relevant data.
- Network with external expert consultants, CRO partners and academic sites to problem solve and develop scientific solutions to clinical pharmacology issues.
- Lead and prepare appropriate documents or sections of clinical protocols, Investigator Brochures, Clinical Study Reports with respect to Clinical Pharmacology studies or data. Participate in the preparation of abstracts and manuscripts for publication.
- Closely partner with Research, Bioanalytical, Clinical functions, Regulatory, Project Management, and other R&D functions.
Skills and experience you’ll bring:
- PharmD or PhD in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with 4-6 years’ experience in pharmaceutical industry.
- Strong working knowledge of pharmacokinetics and modeling, PKPD principles, ADME concepts, and clinical pharmacology.
- Proficient in using Phoenix WinNonlin, NONMEM, R, or other pharmacokinetic and modeling software.
- Strong communication skills (verbal and written) and presentation skills are required.
- Excellent interpersonal skills and the ability to function in a fast-paced and highly matrixed team environment are essential.
Skills and experience not an exact match?:
Go ahead and submit your resume (and a cover letter, if you’d like!). If this role isn't right for you, we can keep you in mind for future opportunities.
Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.
