Associate Director, Chemistry

Company Summary:

FL106 Inc., is a privately held, early-stage biotechnology company developing a groundbreaking genetic medicine technology platform. Our platform integrates experimental and computational approaches to unlock generative design of novel technologies for a wide range of high unmet-need diseases. FL106 is backed by Flagship Pioneering, bringing the vision and resources to guide FL106 from platform validation to real-world solutions that meaningfully improve patient care.

Position Summary:

FL106 is seeking a highly motivated Associate Director with expertise in medicinal chemistry to play a vital role in the company’s efforts to validate novel target discovery approaches. The candidate must be independent, goal oriented, have excellent communication skills and be willing to work in a highly dynamic and fast-paced entrepreneurial environment. This is a unique opportunity to drive the growth of an early-stage biotechnology company where you can contribute to the next frontier of genetic medicines. We are looking for collaborative, enthusiastic problem-solvers to join our team, driven by a shared goal of making a practical impact.

Responsibilities:

• The successful candidate will work both independently and as part of a collaborative team to design, plan and execute experiments that support research activities, project goals and platform development.
• Serve as inaugural member of the team, leading establishment of lab processes, workflows, and assays.
• Drive team excellence by recruiting, training, and mentoring a high-performance biological assay group.
• Oversee and actively contribute to the design and optimization of chemical conjugation, purification, and biophysical and biochemical characterization workflows, supporting and meeting appropriate timelines.
• Serve as a strategic and technical leadership to drive the development of new technologies in genetic medicines.
• Manage out-sourced CRO-based workflows related to medicinal chemistry and assume responsibility for their productivity

Basic Qualifications:

• PhD degree in chemistry or a related field (e.g. organic chemistry, biochemistry, biotechnology or pharmaceutical science), with 8+ years of experience as a medicinal chemist/project leader in the biotech/pharmaceutical industry, including experience in a leadership or a managerial role and a strong publication record
• Candidates of various experience levels will be considered. Position to be determined commensurate with experience.
• Demonstrated deep understanding of state-of-the-art synthetic chemistry methodologies and proficiency in analytical techniques
• Hands-on experience in biorthogonal “click” chemistry techniques for a range of biomolecular compounds including lipids, proteins, nucleic acids, and/or small molecules
• Hands on-experience in implementing biophysical and biochemical analysis and purification techniques (including HPLC, SEC-MALS, DLS).
• Experienced managing various ELN and LIMS systems and ensuring team compliance.
• Excellent communication, presentation, and interpersonal skills, capable of conveying technical information in a clear and thorough manner.
• Demonstrated ability to work in a highly collaborative, team environment, manage multiple projects concurrently, and lead interdisciplinary activities to deliver project milestones
• Motivated and excited about therapeutic and assay development.
• A dynamic problem solver and self-starter

Preferred Qualifications:

• Experience with molecular biology and cellular assays with a variety of readout technologies, such as qPCR, ELISA, flow cytometry and immunofluorescence.
• Experience with LC-MS and/or NMR is nice to have.

About Flagship

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in generation of over 500 patents, initiation of over 50 clinical trials for novel therapeutic agents and an aggregate value of more than $90 billion. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.